Jonathan D. Schertzer, PhD
Jonathan D. Schertzer, PhD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences
Canada Research Chair in Metabolic Immunology
HSC 4H30D
McMaster University
Tel: 905-525-9140 ext. 22254
Email: schertze@mcmaster.ca

Research

The inability to respond to insulin is the major cause of type 2 diabetes. Thisinsulin resistance precedes overt diabetes thereby providing therapeutic window to prevent the disease. Obesity is the main cause of insulin resistance and inflammation has emerged as a key link between obesity and insulin resistance. How does obesity cause inflammation and how does inflammation cause insulin resistance leading to diabetes? My laboratory is interested in understanding these problems in ImmunoMetabolism and how dietary and bacterial factors connect immunology and metabolism. My laboratory uses physiology in genetic mouse models coupled with cell biology and biochemistry to understand the inflammatory basis of metabolic disease. Using our ImmunoMetabolism expertise, we collaborate with immunologists, microbiologists and gastroenterologists in order to understand how the food we eat and the bacteria that colonize us can cause (or prevent) metabolic diseases. This work is particularly interested in how the bacterial cell wall component, peptidoglycan, and dietary factors such as saturated fat propagate inflammation and alter metabolism via nucleotide oligomerization domain (Nod) proteins. This research has important implications for understanding the inflammatory underpinnings of obesity and diabetes, and is complimentary to ongoing collaborative research on energy sensors and fat/glucose metabolism during obesity. My laboratory is also very interested in the role of inflammation in muscle diseases (i.e. myopathies). This builds on a long standing interest in basic science and therapeutics targeted to muscle using both endocrine and gene therapy approaches. Given that statin drugs are the first line treatment for obesity/diabetes related cardiovascular disease, we are particularly interested in immunity and statin-induced myopathy. Working with the world-renowned neuromuscular clinic at McMaster University, we bridge basic aspects of muscle biology and clinical treatment of myopathies such as muscular dystrophy, cancer cachexia, sarcopenia (aging) and inflammatory myopthies.

Selected Publications

  • Gehrig SM, et al. HSP72 preserves muscle function and slows progression of severe muscular dystrophy. Nature, 484: 394-398, 2012
  • Hawley SA, et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science, Apr 19, 2012
  • Galic S, et al. Hematopoietic AMPKβ1 reduces murine adipose tissue macrophage inflammation and hepatic insulin resistance in obesity. J Clin Invest, 121: 4903-4915, 2011
  • O 'Neill HM, et al. AMPKβ1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci USA, 108: 16092-7, 2011
  • Schertzer JD and Klip A. Give a NOD to Insulin Resistance. Am J Physiol Endocrinol Metab 301: E585-6, 2011
  • Schertzer JD, et al. NOD1 activators link innate immunity to insulin resistance. Diabetes 60: 2206-15, 2011
  • Tamrakar AK, et al. NOD2 activation induces muscle cell-autonomous innate immune responses and insulin resistance. Endocrinology 151: 5624-5637, 2010
  • Schertzer JD, et al. A transgenic mouse model to study GLUT4myc regulation in skeletal muscle. Endocrinology 150:1935-40, 2009
  • Schertzer JD, et al. Modulation of IGF-I and IGFBP interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice. Am J Pathol 171: 1180-8, 2007
  • Schertzer JD and Lynch GS. Comparative evaluation of IGF-I gene transfer and IGF-I protein administration for enhancing skeletal muscle regeneration after injury. Gene Ther 13: 1657-64, 2006
  • Schertzer JD, et al. Optimizing plasmid-based gene transfer for investigating skeletal muscle structure and function. Mol Ther 13: 795-803, 2006
Sara Andres, PhD
Sara Andres, PhD Faculty
Department of Biochemistry and Biomedical Sciences Health Sciences Centre, McMaster University
Kjetil Ask, PhD
Kjetil Ask, PhD Associate Member
Assistant Professor, Medicine Firestone Institute for Respiratory Health, Department of Biochemistry and Biomedical Sciences
Stephanie Atkinson, PhD
Stephanie Atkinson, PhD Associate Member
Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences
Paul Berti, PhD
Paul Berti, PhD Joint Member
Associate Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences
Mick Bhatia, PhD
Mick Bhatia, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences, Canada Research Chair
Russell Bishop, PhD
Russell Bishop, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences
Jonathan Bramson, PhD
Jonathan Bramson, PhD Associate Member
Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences
John Brennan, PhD
John Brennan, PhD Associate Member
Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences
Eric D. Brown, PhD
Eric D. Brown, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences,
Director, Biomedical Discovery and Commercialization Program,
Canada Research Chair in Chemical Biology
Lori Burrows, PhD
Lori Burrows, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
Joint Member, Department of Pathology & Molecular Medicine
Brian Coombes, PhD
Brian Coombes, PhD Faculty
Professor and Acting Chair, Department of Biochemistry and Biomedical Sciences, Chair and Assistant Dean, Biochemistry Graduate Program, Canada Research Chair
Bradley Doble, PhD
Bradley Doble, PhD Faculty
Associate Professor, Scientist, McMaster Stem Cell and Cancer Research Institute,
Canada Research Chair
Jonathan Draper, PhD
Jonathan Draper, PhD Joint Member
Assistant Professor, Department of Pathology, Department of Biochemistry and Biomedical Sciences
Marie Elliot, PhD
Marie Elliot, PhD Associate Member
Assistant Professor, Department of Biology, Department of Biochemistry and Biomedical Sciences
Cecile Fradin, PhD
Cecile Fradin, PhD Joint Member
Associate Professor, Department of Physics and Astronomy, Department of Biochemistry and Biomedical Sciences
Radhey S. Gupta, PhD
Radhey S. Gupta, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
John A. Hassell, PhD
John A. Hassell, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences,
Director, Centre for Functional Genomics
Thomas Hawke, PhD
Thomas Hawke, PhD Associate Member
Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences
Paul G. Higgs, PhD
Paul G. Higgs, PhD Joint Member
Professor, Department of Physics and Astronomy, Department of Biochemistry and Biomedical Sciences
Stephen Hill, PhD
Stephen Hill, PhD Associate Member
Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences
Alison Holloway, PHD
Alison Holloway, PHD Associate Member
Associate Professor, Department of Obstetrics and Gynecology, Department of Biochemistry and Biomedical Sciences
Kristin Hope, PhD
Kristin Hope, PhD Faculty
Assistant Professor, Scientist, McMaster Stem Cell and Cancer Research Institute
OICR Investigator
ALEXANDER P. HYNES, PhD

ALEXANDER P. HYNES, PhD
 Associate Member
Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences
CHARU KAUSHIC, PhD
CHARU KAUSHIC, PhD Associate Member
Professor, Department of Pathology and Molecular Medicine
 Department of Biochemistry and Biomedical Sciences
Mark Larché, PhD
Mark Larché, PhD Associate Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences, Canada Research Chair
Yingfu Li, PhD
Yingfu Li, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Nucleic Acids Research
Yu Lu, PhD
Yu Lu, PhD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences
Lesley T. MacNeil, PHD
Lesley T. MacNeil, PHD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Farncombe Family Digestive Health Research Institute
Nathan Magarvey, PhD
Nathan Magarvey, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Jakob Magolan, PhD
Jakob Magolan, PhD Faculty
Boris Family Chair in Drug Discovery
Andrew McArthur, PhD
Andrew McArthur, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences,
Cisco Research Chair in Bioinformatics
Giuseppe Melacini, PhD
Giuseppe Melacini, PhD Joint Member
Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences
Matthew Miller, PhD
Matthew Miller, PhD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences
Karen Mossman, PhD
Karen Mossman, PhD Joint Member
Associate Vice-President (Research), Professor, Department of Pathology and Molecular Biology, Department of Biochemistry and Biomedical Sciences
Ishac Nazy, PhD
Ishac Nazy, PhD Associate Member
Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
GUILLAUME PARÉ, MD, MSc, FRCPC
GUILLAUME PARÉ, MD, MSc, FRCPC Associate Member
Associate Professor, Department of Pathology and Molecular 
Medicine (primary), Department of Clinical Epidemiology and Biostatistics, 
Department of Biochemistry and Biomedical Sciences
Hendrik Poinar, PhD
Hendrik Poinar, PhD Associate Member
Professor, Department of Anthropology, Department of Biochemistry and Biomedical Sciences, Canada Research Chair
Sandeep Raha, PhD
Sandeep Raha, PhD Associate Member
Assistant Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences
Jonathan D. Schertzer, PhD
Jonathan D. Schertzer, PhD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Karun Singh, PhD
Karun Singh, PhD Faculty
Assistant Professor, Stem Cell and Cancer Research Institute,
David Braley Chair in Human Stem Cell Research
Sheila Singh, MD, PhD, FRCSC
Sheila Singh, MD, PhD, FRCSC Associate Member
Assistant Professor, Department of Surgery, Division of Neurosurgery
Deborah Sloboda, PhD
Deborah Sloboda, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Gregory Steinberg, PhD
Gregory Steinberg, PhD Joint Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Michael Surette, PhD
Michael Surette, PhD Joint Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Eva Szabo
Eva Szabo Faculty
Assistant Professor, Stem Cell and Cancer Research Institute,
Canada Research Chair
Bernardo Trigatti, PhD
Bernardo Trigatti, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences
Ray Truant, PhD
Ray Truant, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
Jeffrey Weitz, FRCP(C)-FACP
Jeffrey Weitz, FRCP(C)-FACP Associate Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Geoff Werstuck, PhD
Geoff Werstuck, PhD Joint Member
Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
John Whitney, PhD
John Whitney, PhD Faculty
Assistant Professor in Biochemistry Michael DeGroote Centre for Learning and Discovery (MDCL)
Gerard D. Wright, PhD
Gerard D. Wright, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry
Daniel S.-C. Yang, PhD
Daniel S.-C. Yang, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences