
Matthew Miller, PhD
Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences
MDCL 2324
McMaster University
Tel: 905-525-9140 ext. 22387
Email: mmiller@mcmaster.ca
Visit Matthew Miller's Homepage
Assistant Professor, Department of Biochemistry and Biomedical Sciences
Assistant Dean, Biochemistry Graduate Program
MDCL 2324McMaster University
Tel: 905-525-9140 ext. 22387
Email: mmiller@mcmaster.ca
Visit Matthew Miller's Homepage
Research
The Miller Laboratory is focused on understanding the intimate relationship between viral pathogens and their hosts. Upon infection, both the innate and the adaptive branches of the immune system are mobilized with the aim of protecting the host from virus-mediated pathologies. However, improper regulation of anti-viral immune responses can themselves lead to disease. In addition, viruses have - and continue to - evolve elegant strategies through which to avoid host-mediated immune recognition. Thus, understanding the qualities of immune responses which are effective in protecting the host, as well as those qualities that may cause harm, is essential to informing the development of novel vaccines and therapeutics. The Miller Laboratory is therefore interested in issues concerning both of the innate and adaptive branches of the antiviral response:- The type I interferon system represents the primary innate response pathway initiated upon viral infection. Type I interferons elicit potent cell-intrinsic and cell-extrinsic mechanisms to combat infection. However, when improperly regulated, these responses can lead to devastating immunopathologies. Polymorphisms in genes responsible for regulation of the type I interferon response can therefore have a profound effect on the outcome of viral infections. Our group is interested in understanding how host genetics contribute to the pathological outcome of viral infections. Identification and characterization of these factors will be used to inform more personalized approaches to the treatment of infectious diseases.
- Abnormal inflammation is a signature of many neurodegenerative diseases. However, the way in which inflammation contributes to the pathology of these diseases is poorly defined. We are interested in understanding the role of inflammation in the etiology of neurodegenerative diseases, with a specific focus on its role in amyotrophic lateral sclerosis (ALS).
- Influenza A virus (IAV) presents a particularly formidable challenge to control by the humoral arm of the adaptive immune system. The virus has a segmented, RNA genome which is capable of both rapid mutation (contributing to “antigenic drift”), and re-assortment (which causes “antigenic shift”). These properties allow the virus to cause seasonal epidemics and periodic pandemics, respectively. Current-generation IAV vaccines must be administered seasonally, and provide optimal protection against only a very limited number of IAV strains. However, a new class of antibodies has recently been discovered which is capable of providing much more broad protection across multiple IAV subtypes. Our group is focused on understanding the immunobiology of these antibodies, how they are elicited, and how they may be useful for the generation of “universal” influenza virus vaccines and therapeutics.

Department of Biochemistry and Biomedical Sciences
Health Sciences Centre, McMaster University

Assistant Professor, Medicine Firestone Institute for Respiratory Health,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Chemistry,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences,
Director, Biomedical Discovery and Commercialization Program,
Canada Research Chair in Chemical Biology
Director, Biomedical Discovery and Commercialization Program,
Canada Research Chair in Chemical Biology

Professor, Department of Biochemistry and Biomedical Sciences
Joint Member, Department of Pathology & Molecular Medicine
Joint Member, Department of Pathology & Molecular Medicine

Professor and Chair, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Associate Professor,
Scientist, McMaster Stem Cell and Cancer Research Institute,
Canada Research Chair
Canada Research Chair

Assistant Professor, Department of Pathology,
Department of Biochemistry and Biomedical Sciences

Assistant Professor, Department of Biology, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences,
Director, Centre for Functional Genomics
Director, Centre for Functional Genomics

Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Obstetrics and Gynecology,
Department of Biochemistry and Biomedical Sciences

Assistant Professor,
Scientist, McMaster Stem Cell and Cancer Research Institute
OICR Investigator
OICR Investigator

Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Pathology and Molecular Medicine
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Nucleic Acids Research
Canada Research Chair in Nucleic Acids Research

Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Farncombe Family Digestive Health Research Institute
Farncombe Family Digestive Health Research Institute

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Cisco Research Chair in Bioinformatics
Cisco Research Chair in Bioinformatics

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Assistant Dean, Biochemistry Graduate Program

Associate Vice-President (Research), Professor, Department of Pathology and Molecular Biology,
Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Pathology and Molecular
Medicine (primary), Department of Clinical Epidemiology and Biostatistics,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Anthropology, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Assistant Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Assistant Professor,
Stem Cell and Cancer Research Institute,
David Braley Chair in Human Stem Cell Research
David Braley Chair in Human Stem Cell Research

Assistant Professor, Department of Surgery, Division of Neurosurgery

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Assistant Professor, Stem Cell and Cancer Research Institute,
Canada Research Chair
Canada Research Chair

Associate Professor,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),

Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Assistant Professor in Biochemistry
Michael DeGroote Centre for Learning and Discovery (MDCL)

Professor, Department of Biochemistry and Biomedical Sciences
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry