Matthew Miller, PhD
Matthew Miller, PhD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences
MDCL 2324
McMaster University
Tel: 905-525-9140 ext. 22387
Email: mmiller@mcmaster.ca
Visit Matthew Miller's Homepage

Research

The Miller Laboratory is focused on understanding the intimate relationship between viral pathogens and their hosts. Upon infection, both the innate and the adaptive branches of the immune system are mobilized with the aim of protecting the host from virus-mediated pathologies. However, improper regulation of anti-viral immune responses can themselves lead to disease. In addition, viruses have - and continue to - evolve elegant strategies through which to avoid host-mediated immune recognition. Thus, understanding the qualities of immune responses which are effective in protecting the host, as well as those qualities that may cause harm, is essential to informing the development of novel vaccines and therapeutics. The Miller Laboratory is therefore interested in issues concerning both of the innate and adaptive branches of the antiviral response:
  • The type I interferon system represents the primary innate response pathway initiated upon viral infection. Type I interferons elicit potent cell-intrinsic and cell-extrinsic mechanisms to combat infection. However, when improperly regulated, these responses can lead to devastating immunopathologies. Polymorphisms in genes responsible for regulation of the type I interferon response can therefore have a profound effect on the outcome of viral infections. Our group is interested in understanding how host genetics contribute to the pathological outcome of viral infections. Identification and characterization of these factors will be used to inform more personalized approaches to the treatment of infectious diseases.
  • Abnormal inflammation is a signature of many neurodegenerative diseases. However, the way in which inflammation contributes to the pathology of these diseases is poorly defined. We are interested in understanding the role of inflammation in the etiology of neurodegenerative diseases, with a specific focus on its role in amyotrophic lateral sclerosis (ALS).
  • Influenza A virus (IAV) presents a particularly formidable challenge to control by the humoral arm of the adaptive immune system. The virus has a segmented, RNA genome which is capable of both rapid mutation (contributing to “antigenic drift”), and re-assortment (which causes “antigenic shift”). These properties allow the virus to cause seasonal epidemics and periodic pandemics, respectively. Current-generation IAV vaccines must be administered seasonally, and provide optimal protection against only a very limited number of IAV strains. However, a new class of antibodies has recently been discovered which is capable of providing much more broad protection across multiple IAV subtypes. Our group is focused on understanding the immunobiology of these antibodies, how they are elicited, and how they may be useful for the generation of “universal” influenza virus vaccines and therapeutics.
Sara Andres, PhD
Sara Andres, PhD Faculty
Department of Biochemistry and Biomedical Sciences Health Sciences Centre, McMaster University
Kjetil Ask, PhD
Kjetil Ask, PhD Associate Member
Assistant Professor, Medicine Firestone Institute for Respiratory Health, Department of Biochemistry and Biomedical Sciences
Stephanie Atkinson, PhD
Stephanie Atkinson, PhD Associate Member
Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences
Paul Berti, PhD
Paul Berti, PhD Joint Member
Associate Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences
Mick Bhatia, PhD
Mick Bhatia, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences, Canada Research Chair
Russell Bishop, PhD
Russell Bishop, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences
Jonathan Bramson, PhD
Jonathan Bramson, PhD Associate Member
Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences
John Brennan, PhD
John Brennan, PhD Associate Member
Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences
Eric D. Brown, PhD
Eric D. Brown, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences,
Director, Biomedical Discovery and Commercialization Program,
Canada Research Chair in Chemical Biology
Lori Burrows, PhD
Lori Burrows, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
Joint Member, Department of Pathology & Molecular Medicine
Brian Coombes, PhD
Brian Coombes, PhD Faculty
Professor and Acting Chair, Department of Biochemistry and Biomedical Sciences, Chair and Assistant Dean, Biochemistry Graduate Program, Canada Research Chair
Bradley Doble, PhD
Bradley Doble, PhD Faculty
Associate Professor, Scientist, McMaster Stem Cell and Cancer Research Institute,
Canada Research Chair
Jonathan Draper, PhD
Jonathan Draper, PhD Joint Member
Assistant Professor, Department of Pathology, Department of Biochemistry and Biomedical Sciences
Marie Elliot, PhD
Marie Elliot, PhD Associate Member
Assistant Professor, Department of Biology, Department of Biochemistry and Biomedical Sciences
Cecile Fradin, PhD
Cecile Fradin, PhD Joint Member
Associate Professor, Department of Physics and Astronomy, Department of Biochemistry and Biomedical Sciences
Radhey S. Gupta, PhD
Radhey S. Gupta, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
John A. Hassell, PhD
John A. Hassell, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences,
Director, Centre for Functional Genomics
Thomas Hawke, PhD
Thomas Hawke, PhD Associate Member
Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences
Paul G. Higgs, PhD
Paul G. Higgs, PhD Joint Member
Professor, Department of Physics and Astronomy, Department of Biochemistry and Biomedical Sciences
Stephen Hill, PhD
Stephen Hill, PhD Associate Member
Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences
Alison Holloway, PHD
Alison Holloway, PHD Associate Member
Associate Professor, Department of Obstetrics and Gynecology, Department of Biochemistry and Biomedical Sciences
Kristin Hope, PhD
Kristin Hope, PhD Faculty
Assistant Professor, Scientist, McMaster Stem Cell and Cancer Research Institute
OICR Investigator
ALEXANDER P. HYNES, PhD

ALEXANDER P. HYNES, PhD
 Associate Member
Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences
CHARU KAUSHIC, PhD
CHARU KAUSHIC, PhD Associate Member
Professor, Department of Pathology and Molecular Medicine
 Department of Biochemistry and Biomedical Sciences
Mark Larché, PhD
Mark Larché, PhD Associate Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences, Canada Research Chair
Yingfu Li, PhD
Yingfu Li, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Nucleic Acids Research
Yu Lu, PhD
Yu Lu, PhD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences
Lesley T. MacNeil, PHD
Lesley T. MacNeil, PHD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Farncombe Family Digestive Health Research Institute
Nathan Magarvey, PhD
Nathan Magarvey, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Jakob Magolan, PhD
Jakob Magolan, PhD Faculty
Boris Family Chair in Drug Discovery
Andrew McArthur, PhD
Andrew McArthur, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences,
Cisco Research Chair in Bioinformatics
Giuseppe Melacini, PhD
Giuseppe Melacini, PhD Joint Member
Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences
Matthew Miller, PhD
Matthew Miller, PhD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences
Karen Mossman, PhD
Karen Mossman, PhD Joint Member
Associate Vice-President (Research), Professor, Department of Pathology and Molecular Biology, Department of Biochemistry and Biomedical Sciences
Ishac Nazy, PhD
Ishac Nazy, PhD Associate Member
Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
GUILLAUME PARÉ, MD, MSc, FRCPC
GUILLAUME PARÉ, MD, MSc, FRCPC Associate Member
Associate Professor, Department of Pathology and Molecular 
Medicine (primary), Department of Clinical Epidemiology and Biostatistics, 
Department of Biochemistry and Biomedical Sciences
Hendrik Poinar, PhD
Hendrik Poinar, PhD Associate Member
Professor, Department of Anthropology, Department of Biochemistry and Biomedical Sciences, Canada Research Chair
Sandeep Raha, PhD
Sandeep Raha, PhD Associate Member
Assistant Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences
Jonathan D. Schertzer, PhD
Jonathan D. Schertzer, PhD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Karun Singh, PhD
Karun Singh, PhD Faculty
Assistant Professor, Stem Cell and Cancer Research Institute,
David Braley Chair in Human Stem Cell Research
Sheila Singh, MD, PhD, FRCSC
Sheila Singh, MD, PhD, FRCSC Associate Member
Assistant Professor, Department of Surgery, Division of Neurosurgery
Deborah Sloboda, PhD
Deborah Sloboda, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Gregory Steinberg, PhD
Gregory Steinberg, PhD Joint Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Michael Surette, PhD
Michael Surette, PhD Joint Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Eva Szabo
Eva Szabo Faculty
Assistant Professor, Stem Cell and Cancer Research Institute,
Canada Research Chair
Bernardo Trigatti, PhD
Bernardo Trigatti, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences
Ray Truant, PhD
Ray Truant, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
Jeffrey Weitz, FRCP(C)-FACP
Jeffrey Weitz, FRCP(C)-FACP Associate Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Geoff Werstuck, PhD
Geoff Werstuck, PhD Joint Member
Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
John Whitney, PhD
John Whitney, PhD Faculty
Assistant Professor in Biochemistry Michael DeGroote Centre for Learning and Discovery (MDCL)
Gerard D. Wright, PhD
Gerard D. Wright, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry
Daniel S.-C. Yang, PhD
Daniel S.-C. Yang, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences