Sandeep Raha, PhD
Sandeep Raha, PhD Associate Member
Department of Biochemistry and Biomedical Sciences
Assistant Professor, Department of Pediatrics
3N11j Health Sciences Centre
McMaster University
Tel: 905-521-2100 ext. 76213
Email: rahas@mcmaster.ca
Visit Sandeep Raha's Homepage

Research

Obesity is one of the most significant health care issues of the 21st century because it increases the risk of cardiovascular disease, type 2 diabetes and hypertension. Obesity related dysfunction can potentially be initiated in utero. Children of obese mothers are at a higher risk of becoming obese and developing these risk factors later in life and this serves to further fuel the obesity epidemic. The environment of the fetus, in the womb, may contribute to the child being predisposed towards developing obesity related disorders as a result of metabolic reprogramming. Mitochondria are one of the central players in cellular metabolisms. They have been classically thought of as oval-shaped organelles responsible for generating ATP and supplying the cells energy demands. They are so much more! My lab focuses on understanding the role of mitochondrial function/dysfunction in modulating uterine stress as a consequence of maternal obesity. We focus on how physiological stressors affect mitochondrial function and one of their primary by-products, reactive oxygen species. We are interested in understanding the role of mitochondria in contributing to fetal stress in the obese mother. Furthermore, we also focus on how in utero stress can affect mitochondrial function and signaling in dictating fetal and neonatal health of obese mothers. We utilize cell culture and animal models to understand these processes and develop therapeutic strategies to minimize the consequences of maternal obesity on neonatal health. The range of techniques applied in my laboratory spans molecular approaches (advanced proteomics, RT-PCR, determination of DNA methylation patterns) to cellular (immunological approaches to determining protein expression, enzyme assays, live-cell microscopy, electron microscopy) to physiological methods (evaluation of blood pressure in rodents, determination of glucose tolerance, histology, immunochemistry). In association with clinical collaborators, the scope of the research in my group spans from molecules to humans.
Sara Andres, PhD
Sara Andres, PhD Faculty
Department of Biochemistry and Biomedical Sciences Health Sciences Centre, McMaster University
Kjetil Ask, PhD
Kjetil Ask, PhD Associate Member
Assistant Professor, Medicine Firestone Institute for Respiratory Health, Department of Biochemistry and Biomedical Sciences
Stephanie Atkinson, PhD
Stephanie Atkinson, PhD Associate Member
Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences
Paul Berti, PhD
Paul Berti, PhD Joint Member
Associate Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences
Mick Bhatia, PhD
Mick Bhatia, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences, Canada Research Chair
Russell Bishop, PhD
Russell Bishop, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences
Jonathan Bramson, PhD
Jonathan Bramson, PhD Associate Member
Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences
John Brennan, PhD
John Brennan, PhD Associate Member
Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences
Eric D. Brown, PhD
Eric D. Brown, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences,
Director, Biomedical Discovery and Commercialization Program,
Canada Research Chair in Chemical Biology
Lori Burrows, PhD
Lori Burrows, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
Joint Member, Department of Pathology & Molecular Medicine
Brian Coombes, PhD
Brian Coombes, PhD Faculty
Professor and Chair, Department of Biochemistry and Biomedical Sciences, Canada Research Chair
Bradley Doble, PhD
Bradley Doble, PhD Faculty
Associate Professor, Scientist, McMaster Stem Cell and Cancer Research Institute,
Canada Research Chair
Jonathan Draper, PhD
Jonathan Draper, PhD Joint Member
Assistant Professor, Department of Pathology, Department of Biochemistry and Biomedical Sciences
Marie Elliot, PhD
Marie Elliot, PhD Associate Member
Assistant Professor, Department of Biology, Department of Biochemistry and Biomedical Sciences
Cecile Fradin, PhD
Cecile Fradin, PhD Joint Member
Associate Professor, Department of Physics and Astronomy, Department of Biochemistry and Biomedical Sciences
Radhey S. Gupta, PhD
Radhey S. Gupta, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
John A. Hassell, PhD
John A. Hassell, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences,
Director, Centre for Functional Genomics
Thomas Hawke, PhD
Thomas Hawke, PhD Associate Member
Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences
Paul G. Higgs, PhD
Paul G. Higgs, PhD Joint Member
Professor, Department of Physics and Astronomy, Department of Biochemistry and Biomedical Sciences
Stephen Hill, PhD
Stephen Hill, PhD Associate Member
Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences
Alison Holloway, PHD
Alison Holloway, PHD Associate Member
Associate Professor, Department of Obstetrics and Gynecology, Department of Biochemistry and Biomedical Sciences
Kristin Hope, PhD
Kristin Hope, PhD Faculty
Assistant Professor, Scientist, McMaster Stem Cell and Cancer Research Institute
OICR Investigator
Alexander Hynes, PhD

Alexander Hynes, PhD
 Associate Member
Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences
CHARU KAUSHIC, PhD
CHARU KAUSHIC, PhD Associate Member
Professor, Department of Pathology and Molecular Medicine
 Department of Biochemistry and Biomedical Sciences
Mark Larché, PhD
Mark Larché, PhD Associate Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences, Canada Research Chair
Yingfu Li, PhD
Yingfu Li, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Nucleic Acids Research
Yu Lu, PhD
Yu Lu, PhD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences
Lesley T. MacNeil, PHD
Lesley T. MacNeil, PHD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Farncombe Family Digestive Health Research Institute
Nathan Magarvey, PhD
Nathan Magarvey, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Jakob Magolan, PhD
Jakob Magolan, PhD Faculty
Boris Family Chair in Drug Discovery
Andrew McArthur, PhD
Andrew McArthur, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences,
Cisco Research Chair in Bioinformatics
Giuseppe Melacini, PhD
Giuseppe Melacini, PhD Joint Member
Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences
Matthew Miller, PhD
Matthew Miller, PhD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences, Assistant Dean, Biochemistry Graduate Program
Karen Mossman, PhD
Karen Mossman, PhD Joint Member
Associate Vice-President (Research), Professor, Department of Pathology and Molecular Biology, Department of Biochemistry and Biomedical Sciences
Ishac Nazy, PhD
Ishac Nazy, PhD Associate Member
Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
GUILLAUME PARÉ, MD, MSc, FRCPC
GUILLAUME PARÉ, MD, MSc, FRCPC Associate Member
Associate Professor, Department of Pathology and Molecular 
Medicine (primary), Department of Clinical Epidemiology and Biostatistics, 
Department of Biochemistry and Biomedical Sciences
Hendrik Poinar, PhD
Hendrik Poinar, PhD Associate Member
Professor, Department of Anthropology, Department of Biochemistry and Biomedical Sciences, Canada Research Chair
Sandeep Raha, PhD
Sandeep Raha, PhD Associate Member
Assistant Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences
Jonathan D. Schertzer, PhD
Jonathan D. Schertzer, PhD Faculty
Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Karun Singh, PhD
Karun Singh, PhD Faculty
Assistant Professor, Stem Cell and Cancer Research Institute,
David Braley Chair in Human Stem Cell Research
Sheila Singh, MD, PhD, FRCSC
Sheila Singh, MD, PhD, FRCSC Associate Member
Assistant Professor, Department of Surgery, Division of Neurosurgery
Deborah Sloboda, PhD
Deborah Sloboda, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Gregory Steinberg, PhD
Gregory Steinberg, PhD Joint Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Michael Surette, PhD
Michael Surette, PhD Joint Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Eva Szabo
Eva Szabo Faculty
Assistant Professor, Stem Cell and Cancer Research Institute,
Canada Research Chair
Bernardo Trigatti, PhD
Bernardo Trigatti, PhD Faculty
Associate Professor, Department of Biochemistry and Biomedical Sciences
Ray Truant, PhD
Ray Truant, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
Jeffrey Weitz, FRCP(C)-FACP
Jeffrey Weitz, FRCP(C)-FACP Associate Member
Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Geoff Werstuck, PhD
Geoff Werstuck, PhD Joint Member
Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
John Whitney, PhD
John Whitney, PhD Faculty
Assistant Professor in Biochemistry Michael DeGroote Centre for Learning and Discovery (MDCL)
Gerard D. Wright, PhD
Gerard D. Wright, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry
Daniel S.-C. Yang, PhD
Daniel S.-C. Yang, PhD Faculty
Professor, Department of Biochemistry and Biomedical Sciences