
Alison Holloway, PHD
Associate Member
Division of Reproductive Biology
3N52A Health Sciences Centre
McMaster University
Tel: 905-525-9140 ext. 22130
Email: hollow@mcmaster.ca
Visit Alison Holloway's Homepage
Department of Biochemistry and Biomedical Sciences
Professor, Department of Obstetrics and GynecologyDivision of Reproductive Biology
3N52A Health Sciences Centre
McMaster University
Tel: 905-525-9140 ext. 22130
Email: hollow@mcmaster.ca
Visit Alison Holloway's Homepage
Research
Concerns about the impact of chemical toxicants in the environment on animal and human health are increasing globally. Although there is a growing perception that these chemical insults adversely affect the health of animal and human populations, there is still little information regarding the mechanisms underlying their actions. To date, research attention has focused largely on adverse reproductive effects following exposure to environmental contaminants with estrogenic activity, and has, for the most part, not examined other endocrine or metabolic outcomes. However, it has been suggested that exposure to environmental contaminants may also have an important role in the etiology of metabolic disorders including type 2 diabetes and obesity. The overall goal of my research program is to understand the mechanism(s) by which chemical insults can cause metabolic endocrine disruption in animal and human populations. In particular, I am interested in determining how fetal exposure to chemical insults results in adverse postnatal health outcomes in the offspring including type 2 diabetes and obesity. The chemicals that I am interested in studying include: chemicals we may intentionally expose ourselves to through lifestyle choices such as cigarette smoking or the use of over the counter natural health products; man-made chemicals present in the environment and naturally occurring chemicals in our diet (e.g. plant phytoestrogens). To date the bulk of my research has focused on the long-term health consequences of fetal and neonatal exposure to constituents of cigarette smoke and smoking cessation pharmacotherapies. Specifically we have been examining the mechanisms by which fetal and neonatal exposure to nicotine, as delivered by maternal smoking or nicotine replacement therapy use can result in pancreatic beta cell damage at birth and the development of type 2 diabetes in the adult offspring. My laboratory is also investigating the consequences of fetal exposure to over the counter natural health products, psychiatric medications and man-made chemicals present in the environment on the development of metabolic disorders in adulthood.
Department of Biochemistry and Biomedical Sciences
Health Sciences Centre, McMaster University

Associate Professor, Medicine Firestone Institute for Respiratory Health,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Assistant Professor, Department of Oncology
Department of Biochemistry and Biomedical Sciences

Professor, Department of Chemistry,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Chemical Biology
Canada Research Chair in Chemical Biology

Professor, Department of Biochemistry and Biomedical Sciences
Joint Member, Department of Pathology & Molecular Medicine
Joint Member, Department of Pathology & Molecular Medicine

Professor and Chair, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Professor, Department of Biology, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences,
Director, Centre for Functional Genomics
Director, Centre for Functional Genomics

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Obstetrics and Gynecology,
Department of Biochemistry and Biomedical Sciences

Associate Professor,
Scientist, McMaster Stem Cell and Cancer Research Institute
OICR Investigator
OICR Investigator

Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Pathology and Molecular Medicine
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Nucleic Acids Research
Canada Research Chair in Nucleic Acids Research

Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Farncombe Family Digestive Health Research Institute
Farncombe Family Digestive Health Research Institute

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Director, Biomedical
Discovery & Commercialization Program
Discovery & Commercialization Program

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Assistant Dean, Biochemistry Graduate Program

Associate Vice-President (Research), Professor, Department of Pathology and Molecular Biology,
Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Pathology and Molecular
Medicine (primary), Department of Clinical Epidemiology and Biostatistics,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Anthropology, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Associate Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor,
Stem Cell and Cancer Research Institute,
David Braley Chair in Human Stem Cell Research
David Braley Chair in Human Stem Cell Research

Professor, Department of Surgery, Division of Neurosurgery

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),

Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Assistant Professor in Biochemistry
Michael DeGroote Centre for Learning and Discovery (MDCL)

Professor, Department of Biochemistry and Biomedical Sciences
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry