
Bernardo Trigatti, PhD
Faculty
Tel: 905-521-2100 ext. 40744
Email: trigatt@mcmaster.ca
Visit Dino Trigatti's Homepage
Professor, Department of Biochemistry and Biomedical Sciences
David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton General Hospital CampusTel: 905-521-2100 ext. 40744
Email: trigatt@mcmaster.ca
Visit Dino Trigatti's Homepage
Research
- Cell Biology and Regulation
Molecular mechanisms of atherosclerosis development
Atherosclerosis is a major cause of heart disease and stroke, among the leading causes of hospitalization and death in Western countries. It is a multifactorial disease involving a variety of physiological pathways. These include innate immunity, inflammation and lipoprotein metabolism. Our laboratory utilizes mouse molecular genetics to delineate the contribution of components of these pathways to the development of atherosclerosis. The mouse has been an extremely useful model genetic system to analyze pathways involved in atherosclerosis. In conventional mouse models of atherosclerosis, including the workhorse apoE and LDL receptor knockout mouse strains, atherosclerosis develops primarily in the aorta while coronary arteries, which feed the heart, appear resistant to disease. In contrast, mice that lack a receptor for high density lipoproteins develop extensive atherosclerosis in their coronary arteries as well as increased atherosclerosis in their aortas. These mice develop myocardial infarction as a result of the extensive coronary artery atherosclerosis. This suggests that the HDL receptor, called SR-BI, plays a key role in protection against coronary artery atherosclerosis. One of the main focuses of the lab is to delineate the mechanisms by which expression of SR-BI in bone marrow derived cells including macrophages, protects against atherosclerosis. In particular, we are interested in understanding the role of this receptor in lipid transport as well as cell signalling. We are also making use of our mouse models of coronary artery atherosclerosis to delineate the factors that normally contribute to the resistance of mouse coronary arteries to atherosclerosis development, as well as to test the contribution of different physiological pathways to the development of coronary artery atherosclerosis and myocardial infarction.3
Assistant Professor, Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Assistant Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Oncology,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Chemistry,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Chemical Biology
Canada Research Chair in Chemical Biology

Professor, Department of Biochemistry and Biomedical Sciences,
Joint Member, Department of Pathology & Molecular Medicine,
Acting Director of IIDR
Joint Member, Department of Pathology & Molecular Medicine,
Acting Director of IIDR

Professor and Chair, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Professor, Department of Biology, Department of Biochemistry and Biomedical Sciences

Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Obstetrics and Gynecology,
Department of Biochemistry and Biomedical Sciences

Associate Professor (part-time)
Department of Biochemistry;
Associate Professor, University of Toronto

Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Pathology and Molecular Medicine
,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Professor, Department of Chemistry,
Department of Biochemistry and Biomedical Sciences,
Acting Director BDC,
Canada Research Chair in Nucleic Acids Research
Department of Biochemistry and Biomedical Sciences,
Acting Director BDC,
Canada Research Chair in Nucleic Acids Research

Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Farncombe Family Digestive Health Research Institute
Farncombe Family Digestive Health Research Institute

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor, Department f oBiochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Director, Biomedical
Discovery & Commercialization Program
Discovery & Commercialization Program

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Associate Chair & Assistant Dean, Biochemistry Graduate Program

Associate Vice-President (Research), Professor, Department of Pathology and Molecular Biology,
Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Pathology and Molecular
Medicine (primary), Department of Clinical Epidemiology and Biostatistics,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Anthropology, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Associate Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor (part-time)
Department of Biochemistry;
Associate Professor, University of Toronto

Professor, Department of Surgery, Division of Neurosurgery,
Canada Research Chair
Canada Research Chair

Professor, Department of Biochemistry and Biomedical Sciences,
Associate Chair of Research, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Associate Chair of Research, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Canada Research Chair
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Canada Research Chair

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Michael DeGroote Centre for Learning and Discovery (MDCL)

Professor, Department of Biochemistry and Biomedical Sciences
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry