Bernardo Trigatti, PhD - McMaster Biochemistry Graduate Program

Bernardo Trigatti, PhD Faculty

Professor, Department of Biochemistry and Biomedical Sciences

David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton General Hospital Campus
Tel: 905-521-2100 ext. 40744
Email: trigatt@mcmaster.ca
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Research

Cell Biology and Regulation

Molecular mechanisms of atherosclerosis development

Atherosclerosis is a major cause of heart disease and stroke, among the leading causes of hospitalization and death in Western countries. It is a multifactorial disease involving a variety of physiological pathways. These include innate immunity, inflammation and lipoprotein metabolism. Our laboratory utilizes mouse molecular genetics to delineate the contribution of components of these pathways to the development of atherosclerosis. The mouse has been an extremely useful model genetic system to analyze pathways involved in atherosclerosis. In conventional mouse models of atherosclerosis, including the workhorse apoE and LDL receptor knockout mouse strains, atherosclerosis develops primarily in the aorta while coronary arteries, which feed the heart, appear resistant to disease. In contrast, mice that lack a receptor for high density lipoproteins develop extensive atherosclerosis in their coronary arteries as well as increased atherosclerosis in their aortas. These mice develop myocardial infarction as a result of the extensive coronary artery atherosclerosis. This suggests that the HDL receptor, called SR-BI, plays a key role in protection against coronary artery atherosclerosis. One of the main focuses of the lab is to delineate the mechanisms by which expression of SR-BI in bone marrow derived cells including macrophages, protects against atherosclerosis. In particular, we are interested in understanding the role of this receptor in lipid transport as well as cell signalling. We are also making use of our mouse models of coronary artery atherosclerosis to delineate the factors that normally contribute to the resistance of mouse coronary arteries to atherosclerosis development, as well as to test the contribution of different physiological pathways to the development of coronary artery atherosclerosis and myocardial infarction.3

Sara Andres, PhD Faculty

Assistant Professor, Department of Biochemistry and Biomedical Sciences

Stephanie Atkinson, PhD Associate Member

Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

TOBIAS BERG, MD, PHD Associate Member

Associate Professor, Department of Oncology, Department of Biochemistry and Biomedical Sciences

Paul Berti, PhD Joint Member

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Mick Bhatia, PhD Faculty

Professor, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Russell Bishop, PhD Faculty

Associate Professor, Department of Biochemistry and Biomedical Sciences

Jonathan Bramson, PhD Associate Member

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

John Brennan, PhD Associate Member

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Eric D. Brown, PhD Faculty

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Chemical Biology

Lori Burrows, PhD Faculty

Professor, Department of Biochemistry and Biomedical Sciences,
Joint Member, Department of Pathology & Molecular Medicine,
Acting Director of IIDR

Brian Coombes, PhD Faculty

Professor and Chair, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Marie Elliot, PhD Associate Member

Professor, Department of Biology, Department of Biochemistry and Biomedical Sciences

Cecile Fradin, PhD Joint Member

Professor, Department of Physics and Astronomy, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Radhey S. Gupta, PhD Faculty

Professor, Department of Biochemistry and Biomedical Sciences

Thomas Hawke, PhD Associate Member

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Paul G. Higgs, PhD Joint Member

Professor, Department of Physics and Astronomy, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Stephen Hill, PhD Associate Member

Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Alison Holloway, PHD Associate Member

Associate Professor, Department of Obstetrics and Gynecology, Department of Biochemistry and Biomedical Sciences

Kristin Hope, PhD Part-Time Member

Associate Professor (part-time) Department of Biochemistry; Associate Professor, University of Toronto

Alexander Hynes, PhD  Associate Member

Assistant Professor, Department of Medicine,  Department of Biochemistry and Biomedical Sciences

CHARU KAUSHIC, PhD Associate Member

Professor, Department of Pathology and Molecular Medicine , Department of Biochemistry and Biomedical Sciences

Mark Larché, PhD Associate Member

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Yingfu Li, PhD Joint Member

Professor, Department of Chemistry,
Department of Biochemistry and Biomedical Sciences,
Acting Director BDC,
Canada Research Chair in Nucleic Acids Research

Lesley T. MacNeil, PHD Faculty

Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Farncombe Family Digestive Health Research Institute

Nathan Magarvey, PhD Faculty

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Jakob Magolan, PhD Faculty

Associate Professor, Department f oBiochemistry and Biomedical Sciences,
Canada Research Chair

Andrew McArthur, PhD Faculty

Associate Professor, Department of Biochemistry and Biomedical Sciences, Director, Biomedical
Discovery & Commercialization Program

Giuseppe Melacini, PhD Joint Member

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Matthew Miller, PhD Faculty

Associate Professor, Department of Biochemistry and Biomedical Sciences, Associate Chair & Assistant Dean, Biochemistry Graduate Program

Karen Mossman, PhD Associate Member

Associate Vice-President (Research), Professor, Department of Pathology and Molecular Biology, Department of Biochemistry and Biomedical Sciences

Ishac Nazy, PhD Associate Member

Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

GUILLAUME PARÉ, MD, MSc, FRCPC Associate Member

Associate Professor, Department of Pathology and Molecular  Medicine (primary), Department of Clinical Epidemiology and Biostatistics,  Department of Biochemistry and Biomedical Sciences

Hendrik Poinar, PhD Joint Member

Professor, Department of Anthropology, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Sandeep Raha, PhD Associate Member

Associate Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Jonathan D. Schertzer, PhD Faculty

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Karun Singh, PhD Part-Time Member

Associate Professor (part-time) Department of Biochemistry; Associate Professor, University of Toronto

Sheila Singh, MD, PhD, FRCSC Associate Member

Professor, Department of Surgery, Division of Neurosurgery,
Canada Research Chair

Deborah Sloboda, PhD Faculty

Professor, Department of Biochemistry and Biomedical Sciences,
Associate Chair of Research, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Jennifer Stearns, PhD Associate Member

Assistant Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Gregory Steinberg, PhD Joint Member

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Michael Surette, PhD Joint Member

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Bernardo Trigatti, PhD Faculty

Professor, Department of Biochemistry and Biomedical Sciences

Ray Truant, PhD Faculty

Professor, Department of Biochemistry and Biomedical Sciences

Jeffrey Weitz, FRCP(C)-FACP Associate Member

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Canada Research Chair

Geoff Werstuck, PhD Joint Member

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

John Whitney, PhD Faculty

Assistant Professor, Department of Biochemistry and Biomedical Sciences, Michael DeGroote Centre for Learning and Discovery (MDCL)

Gerard D. Wright, PhD Faculty

Professor, Department of Biochemistry and Biomedical Sciences
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry

Daniel S.-C. Yang, PhD Faculty

Professor, Department of Biochemistry and Biomedical Sciences