
Daniel S.-C. Yang, PhD
Faculty
McMaster University
Tel: 905-525-9140 ext. 22455
Email: yang@mcmaster.ca
Professor, Department of Biochemistry and Biomedical Sciences
4H25A Health Sciences CentreMcMaster University
Tel: 905-525-9140 ext. 22455
Email: yang@mcmaster.ca
Research
- Structural Biology
- Protein/Nucleic Acid Structure/Function
Molecular modeling of protein - protein and protein - ligand interactions
The focus of my current research is in using computational tools to investigate molecular interactions. The main tool is the ZMM program suite and the molecular systems being investigated are ice - antifreeze, ion channels - toxin and cellulose - cellulases. I am also working with Professor Zhorov in using molecular modeling tools to teach biochemistry.Selected Publications
- Solvent Accessibility Properties of Complex Proteins, Sprang, S, Yang, D.S.C. and Fletterick, R.J. (1979),Nature, 280, 333‑5.
- Crystal Structure Of An Antifreeze Polypeptide And Its Mechanistic Implications, Yang, D.S.C., Sax, M., Chakrabartty, A. and Hew, C.L. (1988) Nature, 333, 232-237.
- Antifreeze Protein Produced Endogenously by an Overwintering Plant, Griffith, M., Ala, P., Yang, D.S.C. and Moffatt, B.A. (1992) Plant Physiology 100, 593-596.
- Ice binding structure and mechanism of an antifreeze from winter flounder, Sicheri, F. and Yang, D.S.C. (1995) Nature 375, 427-431.
- Antifreeze proteins in winter rye are similar to pathogenesis-related proteins, Hon. W.-C., Griffith, M., Mlynarz, A., Kwok, Y.C. and Yang, D.S.C. (1995) Plant Physiol. 109, 879-889.
- Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases, Hon, W.C., McKay, G.A., Thompson, P.R., Sweet, R.M., Yang, D.S.C., Wright, G.D. and Berghuis, A.M. (1997). Cell, 89, 887-895.
- Identification of the ice-binding surface on a type III AFP with a “flatness function” algorithm, Yang,D.S.C., Hon, W.-C., Bubanko,S., Xue,Y.Q., Seetharaman,J., Hew,C.L. & Sicheri,F. (1998). Biophysical Journal, 74: 2142-2151.
- Bone recognition mechanism of porcine osteocalcin from crystal structure. Hoang QQ, Sicheri F, Howard AJ, Yang DS. (2003). Nature. 425(6961):977-80.
- Theoretical study of interaction of winter flounder antifreeze protein with ice. Jorov A, Zhorov BS, Yang DS. (2004). Protein Sci. 13(6):1524-37.
- Self-cleavable stimulus responsive tags for protein purification without chromatography. Ge X, Yang DS, TrabbicCarlson K, Kim B, Chilkoti A, Filipe CD. (2005) JACS. 127(32): 11228-9.
- Characterization of the C-terminal Domain of a Potassium Channel from Streptomyces lividans (KcsA). Pau VP, Zhu Y, Yuchi Z, Hoang QQ, Yang DS. (2007) J. Biol. Chem. 282(40):29163-9.
- GCN4 enhances the stability of the pore domain of potassium channel KcsA. Yuchi Z, Pau VP, Yang DS. (2008) FEBS J. 275(24):6228-36.
- An engineered right-handed coiled coil domain imparts extreme thermostability to the KcsA channel. Yuchi Z, Pau VP, Lu BX, Junop M, Yang DS. (2009) FEBS J. 276(21):6236-46.

Department of Biochemistry and Biomedical Sciences
Health Sciences Centre, McMaster University

Associate Professor, Medicine Firestone Institute for Respiratory Health,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Assistant Professor, Department of Oncology
Department of Biochemistry and Biomedical Sciences

Professor, Department of Chemistry,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Chemical Biology
Canada Research Chair in Chemical Biology

Professor, Department of Biochemistry and Biomedical Sciences
Joint Member, Department of Pathology & Molecular Medicine
Joint Member, Department of Pathology & Molecular Medicine

Professor and Chair, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Professor, Department of Biology, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences,
Director, Centre for Functional Genomics
Director, Centre for Functional Genomics

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Obstetrics and Gynecology,
Department of Biochemistry and Biomedical Sciences

Associate Professor,
Scientist, McMaster Stem Cell and Cancer Research Institute
OICR Investigator
OICR Investigator

Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Pathology and Molecular Medicine
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Nucleic Acids Research
Canada Research Chair in Nucleic Acids Research

Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Farncombe Family Digestive Health Research Institute
Farncombe Family Digestive Health Research Institute

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Director, Biomedical
Discovery & Commercialization Program
Discovery & Commercialization Program

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Assistant Dean, Biochemistry Graduate Program

Associate Vice-President (Research), Professor, Department of Pathology and Molecular Biology,
Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Pathology and Molecular
Medicine (primary), Department of Clinical Epidemiology and Biostatistics,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Anthropology, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Associate Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor,
Stem Cell and Cancer Research Institute,
David Braley Chair in Human Stem Cell Research
David Braley Chair in Human Stem Cell Research

Professor, Department of Surgery, Division of Neurosurgery

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),

Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Assistant Professor in Biochemistry
Michael DeGroote Centre for Learning and Discovery (MDCL)

Professor, Department of Biochemistry and Biomedical Sciences
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry