
Sandeep Raha, PhD
Associate Member
3N11j Health Sciences Centre
McMaster University
Tel: 905-521-2100 ext. 76213
Email: rahas@mcmaster.ca
Visit Sandeep Raha's Homepage
Department of Biochemistry and Biomedical Sciences
Associate Professor, Department of Pediatrics3N11j Health Sciences Centre
McMaster University
Tel: 905-521-2100 ext. 76213
Email: rahas@mcmaster.ca
Visit Sandeep Raha's Homepage
Research
Obesity is one of the most significant health care issues of the 21st century because it increases the risk of cardiovascular disease, type 2 diabetes and hypertension. Obesity related dysfunction can potentially be initiated in utero. Children of obese mothers are at a higher risk of becoming obese and developing these risk factors later in life and this serves to further fuel the obesity epidemic. The environment of the fetus, in the womb, may contribute to the child being predisposed towards developing obesity related disorders as a result of metabolic reprogramming. Mitochondria are one of the central players in cellular metabolisms. They have been classically thought of as oval-shaped organelles responsible for generating ATP and supplying the cells energy demands. They are so much more! My lab focuses on understanding the role of mitochondrial function/dysfunction in modulating uterine stress as a consequence of maternal obesity. We focus on how physiological stressors affect mitochondrial function and one of their primary by-products, reactive oxygen species. We are interested in understanding the role of mitochondria in contributing to fetal stress in the obese mother. Furthermore, we also focus on how in utero stress can affect mitochondrial function and signaling in dictating fetal and neonatal health of obese mothers. We utilize cell culture and animal models to understand these processes and develop therapeutic strategies to minimize the consequences of maternal obesity on neonatal health. The range of techniques applied in my laboratory spans molecular approaches (advanced proteomics, RT-PCR, determination of DNA methylation patterns) to cellular (immunological approaches to determining protein expression, enzyme assays, live-cell microscopy, electron microscopy) to physiological methods (evaluation of blood pressure in rodents, determination of glucose tolerance, histology, immunochemistry). In association with clinical collaborators, the scope of the research in my group spans from molecules to humans.
Assistant Professor, Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Assistant Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Oncology,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Chemistry,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Chemical Biology
Canada Research Chair in Chemical Biology

Professor, Department of Biochemistry and Biomedical Sciences,
Joint Member, Department of Pathology & Molecular Medicine,
Acting Director of IIDR
Joint Member, Department of Pathology & Molecular Medicine,
Acting Director of IIDR

Professor and Chair, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Professor, Department of Biology, Department of Biochemistry and Biomedical Sciences

Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Obstetrics and Gynecology,
Department of Biochemistry and Biomedical Sciences

Associate Professor (part-time)
Department of Biochemistry;
Associate Professor, University of Toronto

Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Pathology and Molecular Medicine
,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Professor, Department of Chemistry,
Department of Biochemistry and Biomedical Sciences,
Acting Director BDC,
Canada Research Chair in Nucleic Acids Research
Department of Biochemistry and Biomedical Sciences,
Acting Director BDC,
Canada Research Chair in Nucleic Acids Research

Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Farncombe Family Digestive Health Research Institute
Farncombe Family Digestive Health Research Institute

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor, Department f oBiochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Director, Biomedical
Discovery & Commercialization Program
Discovery & Commercialization Program

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Associate Chair & Assistant Dean, Biochemistry Graduate Program

Associate Vice-President (Research), Professor, Department of Pathology and Molecular Biology,
Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Pathology and Molecular
Medicine (primary), Department of Clinical Epidemiology and Biostatistics,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Anthropology, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Associate Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor (part-time)
Department of Biochemistry;
Associate Professor, University of Toronto

Professor, Department of Surgery, Division of Neurosurgery,
Canada Research Chair
Canada Research Chair

Professor, Department of Biochemistry and Biomedical Sciences,
Associate Chair of Research, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Associate Chair of Research, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Canada Research Chair
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Canada Research Chair

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Michael DeGroote Centre for Learning and Discovery (MDCL)

Professor, Department of Biochemistry and Biomedical Sciences
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry