
Thomas Hawke, PhD
Associate Member
McMaster University
Tel: 905-525-9140 ext. 22372
Email: hawke@mcmaster.ca
Visit Thomas Hawke's webpage
Professor, Department of Pathology and Molecular Medicine
HSC 4N65McMaster University
Tel: 905-525-9140 ext. 22372
Email: hawke@mcmaster.ca
Visit Thomas Hawke's webpage
Research
Dr. Hawke’s research focus is on the role and regulation of muscle satellite cells, the stem cell population of skeletal muscle, in health and disease states such as diabetes mellitus and limb girdle muscular dystrophy. Skeletal muscle has an amazing capacity to regenerate following injury. The injury may be induced by a number of factors including heavy exercise, trauma or disease. The regenerative capacity of skeletal muscle is due primarily to a rare population of progenitor cells called muscle satellite cells. These cells have many characteristics of stem cells, including the capacity divide numerous times, self-renew their population and enter a state of quiescence when they are not needed. The potential of this cell population is tremendous, however, the use of these cells for cell transplantation into patients with myopathies has yielded disappointing results. This is mostly due to a lack of knowledge regarding the regulatory mechanisms controlling these cells. It is only through a more thorough understanding of this cell population that their therapeutic potential be realized. Using molecular, cellular and physiological techniques, we are attempting to define the regulation of this cell population in health and disease.Techniques used in the lab include: histology, immunohistochemistry, protein and RNA expression assays, isolated single fibre and primary myoblast cultures, in situ muscle stimulation to assess contractile function, adenoviral mediated overexpression and/or silencing and metabolic enzyme assays.
Department of Biochemistry and Biomedical Sciences
Health Sciences Centre, McMaster University

Associate Professor, Medicine Firestone Institute for Respiratory Health,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Assistant Professor, Department of Oncology
Department of Biochemistry and Biomedical Sciences

Professor, Department of Chemistry,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Chemical Biology
Canada Research Chair in Chemical Biology

Professor, Department of Biochemistry and Biomedical Sciences
Joint Member, Department of Pathology & Molecular Medicine
Joint Member, Department of Pathology & Molecular Medicine

Professor and Chair, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair

Professor, Department of Biology, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Biochemistry and Biomedical Sciences,
Director, Centre for Functional Genomics
Director, Centre for Functional Genomics

Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Physics and Astronomy,
Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Pathology and Molecular Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Obstetrics and Gynecology,
Department of Biochemistry and Biomedical Sciences

Associate Professor,
Scientist, McMaster Stem Cell and Cancer Research Institute
OICR Investigator
OICR Investigator

Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Pathology and Molecular Medicine
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair in Nucleic Acids Research
Canada Research Chair in Nucleic Acids Research

Assistant Professor, Department of Biochemistry and Biomedical Sciences,
Farncombe Family Digestive Health Research Institute
Farncombe Family Digestive Health Research Institute

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Director, Biomedical
Discovery & Commercialization Program
Discovery & Commercialization Program

Professor, Department of Chemistry, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Assistant Dean, Biochemistry Graduate Program

Associate Vice-President (Research), Professor, Department of Pathology and Molecular Biology,
Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Pathology and Molecular
Medicine (primary), Department of Clinical Epidemiology and Biostatistics,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Anthropology, Department of Biochemistry and Biomedical Sciences, Canada Research Chair

Associate Professor, Department of Pediatrics, Department of Biochemistry and Biomedical Sciences

Associate Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Associate Professor,
Stem Cell and Cancer Research Institute,
David Braley Chair in Human Stem Cell Research
David Braley Chair in Human Stem Cell Research

Professor, Department of Surgery, Division of Neurosurgery

Professor, Department of Biochemistry and Biomedical Sciences,
Canada Research Chair
Canada Research Chair

Assistant Professor, Department of Medicine,
Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),
Director, Thrombosis & Atherosclerosis Research Institute (TaARI),

Associate Professor, Department of Medicine, Department of Biochemistry and Biomedical Sciences

Assistant Professor in Biochemistry
Michael DeGroote Centre for Learning and Discovery (MDCL)

Professor, Department of Biochemistry and Biomedical Sciences
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry
Director, Michael DeGroote Institute for Infectious Disease Research
Canada Research Chair in Antimicrobial Biochemistry